Transcriptional profiling of the iron starvation response in Bordetella pertussis provides new insights into siderophore utilization and virulence gene expression.

@article{Brickman2011TranscriptionalPO,
  title={Transcriptional profiling of the iron starvation response in Bordetella pertussis provides new insights into siderophore utilization and virulence gene expression.},
  author={Timothy J. Brickman and Craig A. Cummings and Sarah Joan Liew and David A. Relman and Sandra K Armstrong},
  journal={Journal of bacteriology},
  year={2011},
  volume={193 18},
  pages={
          4798-812
        }
}
Serological studies of patients with pertussis and the identification of antigenic Bordetella pertussis proteins support the hypothesis that B. pertussis perceives an iron starvation cue and expresses multiple iron source utilization systems in its natural human host environment. Furthermore, previous studies using a murine respiratory tract infection model showed that several of these B. pertussis iron systems are required for colonization and persistence and are differentially expressed over… CONTINUE READING
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