Transcriptional profiling of subjects from the Iowa adoption studies.

  title={Transcriptional profiling of subjects from the Iowa adoption studies.},
  author={Robert A Philibert and G Ryu and Jae-geun Yoon and Harinder Sandhu and Nancy Hollenbeck and T Zachary Gunter and Amanda Barkhurst and William J. Adams and Anup Madan},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  volume={144B 5},
Transcriptional profiling has been used to identify gene expression patterns indicative of general medical illnesses such as atherosclerosis. However, whether these methods can identify common psychiatric disorders has not been established. To answer this question with respect to nicotine use, we used genome-wide expression profiling lymphoblast cell lines from six actively smoking Iowa Adoption Studies (IAS) subjects and nine "clean" control subjects, followed by real-time PCR (RT-PCR) of gene… CONTINUE READING
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