Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro.

  title={Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro.},
  author={G. Dow and D. Caridha and Michelle Goldberg and L. Wolf and M. Koenig and D. Yourick and Z. Wang},
  volume={86 5},
  • G. Dow, D. Caridha, +4 authors Z. Wang
  • Published 2005
  • Biology, Medicine
  • Genomics
  • Mefloquine is associated with adverse neurological effects that are mediated via unknown mechanisms. Recent in vitro studies have shown that mefloquine disrupts neuronal calcium homeostasis via liberation of the endoplasmic reticulum (ER) store and induction of calcium influx across the plasma membrane. In the present study, global changes in gene expression induced in neurons in response to mefloquine-induced disruption of calcium homeostasis and appropriate control agents were investigated in… CONTINUE READING
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