Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro.

@article{Dow2005TranscriptionalPO,
  title={Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro.},
  author={G. Dow and D. Caridha and Michelle Goldberg and L. Wolf and M. Koenig and D. Yourick and Z. Wang},
  journal={Genomics},
  year={2005},
  volume={86 5},
  pages={
          539-50
        }
}
  • G. Dow, D. Caridha, +4 authors Z. Wang
  • Published 2005
  • Biology, Medicine
  • Genomics
  • Mefloquine is associated with adverse neurological effects that are mediated via unknown mechanisms. Recent in vitro studies have shown that mefloquine disrupts neuronal calcium homeostasis via liberation of the endoplasmic reticulum (ER) store and induction of calcium influx across the plasma membrane. In the present study, global changes in gene expression induced in neurons in response to mefloquine-induced disruption of calcium homeostasis and appropriate control agents were investigated in… CONTINUE READING
    20 Citations
    Mefloquine-Induced Disruption of Calcium Homeostasis in Mammalian Cells Is Similar to That Induced by Ionomycin
    • 43
    • PDF
    Mefloquine induces oxidative stress and neurodegeneration in primary rat cortical neurons.
    • 35
    • Highly Influenced
    • PDF
    Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling
    • 26
    • Highly Influenced
    • PDF
    Bax inhibitor 1, a modulator of calcium homeostasis, confers affective resilience
    • 29
    Mefloquine induces cell death in prostate cancer cells and provides a potential novel treatment strategy in vivo
    • 17
    • Highly Influenced
    • PDF
    Epileptogenic potential of mefloquine chemoprophylaxis: a pathogenic hypothesis
    • 18
    Impaired endoplasmic reticulum stress response in bipolar disorder: cellular evidence of illness progression.
    • 36
    • PDF

    References

    SHOWING 1-10 OF 50 REFERENCES
    Brain injury: prolonged induction of transcription factors.
    • 35
    • PDF
    Inhibition of volume-regulated and calcium-activated chloride channels by the antimalarial mefloquine.
    • 44
    • PDF
    Compensatory responses to inhibition of hepatic squalene synthase.
    • 22
    Effects of mefloquine on Ca2+ uptake by crude microsomes of rabbit skeletal muscle.
    • M. Go, H. Lee, P. Palade
    • Chemistry, Medicine
    • Archives internationales de pharmacodynamie et de therapie
    • 1995
    • 8
    The antimalarial agent mefloquine inhibits ATP‐sensitive K‐channels
    • 75
    Activating Transcription Factor 3 Is Integral to the Eukaryotic Initiation Factor 2 Kinase Stress Response
    • 450
    • PDF