Transcriptional profiling of hypothalamus during development of adiposity in genetically selected fat and lean chickens.

@article{Byerly2010TranscriptionalPO,
  title={Transcriptional profiling of hypothalamus during development of adiposity in genetically selected fat and lean chickens.},
  author={Mardi S. Byerly and Jean Simon and Larry A. Cogburn and Elisabeth Le Bihan-Duval and Michel Jean Duclos and Samuel E. Aggrey and Tom E. Porter},
  journal={Physiological genomics},
  year={2010},
  volume={42 2},
  pages={157-67}
}
The hypothalamus integrates peripheral signals to regulate food intake, energy metabolism, and ultimately growth rate and body composition in vertebrates. Deviations in hypothalamic regulatory controls can lead to accumulation of excess body fat. Many regulatory genes involved in this process remain unidentified, and comparative studies may be helpful to unravel evolutionarily conserved mechanisms controlling body weight and food intake. In the present study, divergently selected fat (FL) and… CONTINUE READING