Transcriptional profiling of genes at the human common fragile site FRA1H in tumor-derived cell lines.

@article{Pelliccia2007TranscriptionalPO,
  title={Transcriptional profiling of genes at the human common fragile site FRA1H in tumor-derived cell lines.},
  author={Franca Pelliccia and Angela Curatolo and Zaira M Limongi and Nazario Bosco and Angela Rocchi},
  journal={Cancer genetics and cytogenetics},
  year={2007},
  volume={178 2},
  pages={
          144-50
        }
}
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DIFFERENTIAL INVOLVEMENT OF S AND L ISOFORMS OF THE CENTROSOMAL MARK4 KINASE IN GLIOMA INITIATION AND PROGRESSION
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IARS2 silencing induces non-small cell lung cancer cells proliferation inhibition, cell cycle arrest and promotes cell apoptosis.
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References

SHOWING 1-10 OF 31 REFERENCES
Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells
TLDR
The hypothesis that common fragile sites and their associated genes are, in general, unstable in some cancer cells is supported, including FRAXB, which is not associated with any known tumor suppressor genes or activity.
Molecular characterization of the human common fragile site FRA1H
TLDR
The FRA1H DNA sequence was analyzed to identify coding sequences, the AT content, the type and quantity of the DNA repeats, the CpG islands, the matrix attachment regions, and the number and distribution of high‐flexibility regions and a 120 kb long sequence was identified that may be involved in inducing fragility in the surrounding regions.
Common chromosomal fragile site FRA16D mutation in cancer cells.
TLDR
Identical FRA16D deleting cells retain cytogenetic fragile site expression indicating that the deletions are susceptible sites for breakage rather than regions that confer fragility, therefore common fragile sites represent highly susceptible genome-wide targets for a distinct form of mutation.
Characterization of the common fragile site FRA9E and its potential role in ovarian cancer
TLDR
Evidence is provided to suggest that instability within FRA9E may play an important role in the development of ovarian cancer and lends further support for the hypothesis that CFSs may be causally related to cancer.
Alterations in the common fragile site gene Parkin in ovarian and other cancers
TLDR
Analysis of Parkin protein expression with antibodies revealed that most of the ovarian cancer cell lines and primary tumors had diminished or absent Parkin expression, suggesting that like FHIT and WWOX, Parkin may represent a tumor suppressor gene.
Common fragile sites
TLDR
Findings showing that the key checkpoint genes ATR and BRCA1 are critical for genome stability at fragile sites have shed new light on these mechanisms and on the biological significance of common fragile sites.
MicroRNAs and chromosomal abnormalities in cancer cells
TLDR
Over the past five decades, a plethora of nonrandom chromosomal abnormalities have been consistently reported in malignant cells facilitating the identification of cancer-associated protein coding oncogenes and tumor suppressors, and selective targeting of these noncoding genes could provide novel therapeutic options for killing themalignant cells.
MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias.
TLDR
Genomewide expression profiling of miRNAs in human B cell chronic lymphocytic leukemia (CLL) is reported by using a microarray containing hundreds of human precursor and mature miRNA oligonucleotide probes, suggesting that miRNA expression patterns have relevance to the biological and clinical behavior of this leukemia.
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