Transcriptional profiling of brain-derived-neurotrophic factor-induced neuronal plasticity: a novel role for nociceptin in hippocampal neurite outgrowth.

@article{Ring2006TranscriptionalPO,
  title={Transcriptional profiling of brain-derived-neurotrophic factor-induced neuronal plasticity: a novel role for nociceptin in hippocampal neurite outgrowth.},
  author={Robert H Ring and Janet Alder and Myles Fennell and Evguenia Kouranova and Ira B. Black and Smita Thakker-Varia},
  journal={Journal of neurobiology},
  year={2006},
  volume={66 4},
  pages={361-77}
}
Brain derived neurotrophic factor (BDNF) exhibits a sequence of actions on neurons ranging from acute enhancement of transmission to long-term promotion of neurite outgrowth and synaptogenesis associated with learning and memory. The manifold effects of BDNF on neuronal modifications may be mediated by genomic alterations. We previously found that BDNF treatment acutely increases transcription of the synaptic vesicle protein Rab3A, required for trophin-induced synaptic plasticity, as well as… CONTINUE READING