Transcriptional profiling of a mice plague model: insights into interaction between Yersinia pestis and its host.

@article{Liu2009TranscriptionalPO,
  title={Transcriptional profiling of a mice plague model: insights into interaction between Yersinia pestis and its host.},
  author={Haihong Liu and Hong Wang and Jingfu Qiu and Xiaoyi Wang and Zhaobiao Guo and Yefeng Qiu and Dongsheng Zhou and Yanping Han and Zongmin Du and Cai Fu Li and Yajun Song and Ruifu Yang},
  journal={Journal of basic microbiology},
  year={2009},
  volume={49 1},
  pages={92-9}
}
Despite the importance of pneumonic plague caused by Yersinia pestis, a few is known about the interaction between Y. pestis and its host at the molecular level during the pneumonic plague development. In this study, we employed an intranasally challenged plague model in mice for investigating the kinetics of the disease progression by transcriptional profiling of Y. pestis and mice using qRT-PCR and microarray, respectively. The increasing transcription of important virulence genes of Y… CONTINUE READING

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