Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation.

  title={Transcriptional profiling of Kr{\"u}ppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation.},
  author={Xinming Chen and Erika M Whitney and Shu Y Gao and Vincent W. Yang},
  journal={Journal of molecular biology},
  volume={326 3},
Krüppel-like factor 4 (KLF4) is an epithelially enriched, zinc finger-containing transcription factor, the expression of which is associated with growth arrest. Constitutive expression of KLF4 inhibits G1/S transition of the cell cycle but the manner by which it accomplishes this effect is unclear. To better understand the biochemical function of KLF4, we identified its target genes using cDNA microarray analysis in an established human cell line containing inducible KLF4. RNA extracted from… CONTINUE READING

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