Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family

@article{Greiss2008TranscriptionalPI,
  title={Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family},
  author={Sebastian Greiss and Bj{\"o}rn Schumacher and Kaj Grandien and Jonathan Rothblatt and Anton Gartner},
  journal={BMC Genomics},
  year={2008},
  volume={9},
  pages={334 - 334}
}
BackgroundIn contrast to the three mammalian p53 family members, p53, which is generally involved in DNA damage responses, and p63 and p73 which are primarily needed for developmental regulation, cep-1 encodes for the single C. elegansp 53-like gene. cep-1 acts as a transcription activator in a primordial p53 pathway that involves CEP-1 activation and the CEP-1 dependent transcriptional induction of the worm BH3 only domain encoding genes egl-1 and ced-13 to induce germ cell apoptosis. EGL-1… CONTINUE READING

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