Transcriptional profiling identifies Id2 function in dendritic cell development

@article{Hacker2003TranscriptionalPI,
  title={Transcriptional profiling identifies Id2 function in dendritic cell development},
  author={Christine Hacker and Ralf D. Kirsch and Xinsheng Ju and Thomas Hieronymus and Tatjana C. Gust and Christiane Kuhl and Thorsten Jorgas and Steffen M. Kurz and Stefan Rose-John and Yoshifumi Yokota and Martin Zenke},
  journal={Nature Immunology},
  year={2003},
  volume={4},
  pages={380-386}
}
Dendritic cells (DCs) are potent antigen-presenting cells with a pivotal role in antigen-specific immune responses. Here, we found that the helix-loop-helix transcription factor Id2 is up-regulated during DC development in vitro and crucial for the development of distinct DC subsets in vivo. Id2−/− mice lack Langerhans cells (LCs), the cutaneous contingent of DCs, and the splenic CD8α+ DC subset is markedly reduced. Mice deficient for transforming growth factor (TGF)-β also lack LCs, and we… 
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