Transcriptional profiles of valvular and vascular endothelial cells reveal phenotypic differences: influence of shear stress.


OBJECTIVE The similarities between valvular and vascular lesions suggest pathological initiation mediated through endothelium, but the role of hemodynamics in valvular endothelial biology is poorly understood. METHODS AND RESULTS Monolayers of porcine aortic endothelial cells (PAECs) or porcine aortic valve endothelial cells (PAVECs) were exposed to 20… (More)


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