Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir.

@article{Lin2003TranscriptionalPO,
  title={Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir.},
  author={Xin Lin and Dan Irwin and Satoshi Kanazawa and Laurence Huang and Joseph Romeo and T. S. Benedict Yen and Boris Matija Peterlin},
  journal={Journal of virology},
  year={2003},
  volume={77 15},
  pages={8227-36}
}
The persistence of human immunodeficiency virus (HIV) in optimally treated infected individuals poses a major therapeutic problem. In latently infected cells, one of the observed phenotypes is absent elongation of viral transcription. Thus, the positive elongation factor b (P-TEFb), which is usually recruited by NF-kappaB or Tat, is not present on the HIV long terminal repeat (LTR). Although most attempts to activate these proviruses centered on NF-kappaB, we investigated effects of Tat. To… CONTINUE READING