Transcriptional profiles in CD8+ T cells from HIV+ progressors on HAART are characterized by coordinated up-regulation of oxidative phosphorylation enzymes and interferon responses.

@article{Wu2008TranscriptionalPI,
  title={Transcriptional profiles in CD8+ T cells from HIV+ progressors on HAART are characterized by coordinated up-regulation of oxidative phosphorylation enzymes and interferon responses.},
  author={Jing Wu and Dominic Edmund Dwyer and Wayne B. Dyer and Yee Hwa Yang and Bin Wang and Nitin K Saksena},
  journal={Virology},
  year={2008},
  volume={380 1},
  pages={124-35}
}
The functional impairment and numerical decline of CD8+ T cells during HIV infection has a profound effect on disease progression, but only limited microarray studies have used CD8+ T cells. To understand the interactions of HIV and host CD8+ T cells at different disease status, we used the Illumina Human-6 BeadChips to evaluate the transcriptional profile (>48,000 transcripts) in primary CD8+ T cells from HIV+ therapy-naive non-progressors and therapy-experienced progressors. 68 differentially… CONTINUE READING
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