Transcriptional profile of right ventricular tissue during acute pulmonary embolism in rats.

@article{Zagorski2008TranscriptionalPO,
  title={Transcriptional profile of right ventricular tissue during acute pulmonary embolism in rats.},
  author={John Zagorski and Nina Sanapareddy and Michael Aaron Gellar and Jeffrey A. Kline and John Albert Watts},
  journal={Physiological genomics},
  year={2008},
  volume={34 1},
  pages={101-11}
}
Acute pulmonary embolism (PE) is the third leading cause of cardiovascular death in the United States. Moderate to severe PE can cause pulmonary arterial hypertension (PH) with resultant right ventricular (RV) heart damage. The mechanisms leading to RV failure after PE are not well defined, although it is becoming clear that PH-induced inflammatory responses are involved. We previously demonstrated profound neutrophil-mediated inflammation and RV dysfunction during PE that was associated with… CONTINUE READING