Transcriptional priming of intrathymic precursors for dendritic cell development.

  title={Transcriptional priming of intrathymic precursors for dendritic cell development.},
  author={Amanda J. Moore and Janice Sarmiento and Mahmood Mohtashami and Marsela Braunstein and Juan-Carlos Z{\'u}{\~n}iga-Pfl{\"u}cker and Michele K Anderson},
  volume={139 2},
Specialized dendritic cells (DCs) within the thymus are crucial for the deletion of autoreactive T cells. The question of whether these cells arise from intrathymic precursors with T-cell potential has been hotly debated, and the regulatory pathways and signals that direct their development remain unclear. Here, we compared the gene expression profiles of thymic DC subsets with those of four early thymic precursor subsets: early T-cell precursors (ETPs), double-negative 1c (DN1c), double… CONTINUE READING


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Method Support
Highly Influenced


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