Transcriptional pausing caused by NELF plays a dual role in regulating immediate-early expression of the junB gene.

@article{Aida2006TranscriptionalPC,
  title={Transcriptional pausing caused by NELF plays a dual role in regulating immediate-early expression of the junB gene.},
  author={Masatoshi Aida and Yexi Chen and Koichi Nakajima and Yuki Yamaguchi and Tadashi Wada and Hiroshi Handa},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 16},
  pages={6094-104}
}
Human 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity-inducing factor (DSIF) and negative elongation factor (NELF) negatively regulate transcription elongation by RNA polymerase II (RNAPII) in vitro. However, the physiological roles of this negative regulation are not well understood. Here, by using a number of approaches to identify protein-DNA interactions in vivo, we show that DSIF- and NELF-mediated transcriptional pausing has a dual function in regulating immediate-early… CONTINUE READING

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