Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16.

  title={Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16.},
  author={Joshua J McElwee and Kerry L. Bubb and James Harold Thomas},
  journal={Aging cell},
  volume={2 2},
In Caenorhabditis elegans, the forkhead protein DAF-16 transduces insulin-like signals that regulate larval development and adult lifespan. To identify DAF-16-dependent transcriptional alterations that occur in a long-lived C. elegans strain, we used cDNA microarrays and genomic analysis to identify putative direct and indirect DAF-16 transcriptional target genes. Our analysis suggests that DAF-16 action regulates a wide range of physiological responses by altering the expression of genes… CONTINUE READING
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