Transcriptional organization and regulation of an antibiotic export complex in the producing Streptomyces culture

@article{Caballero1991TranscriptionalOA,
  title={Transcriptional organization and regulation of an antibiotic export complex in the producing Streptomyces culture},
  author={J Caballero and Francisco Malpartida and David A. Hopwood},
  journal={Molecular and General Genetics MGG},
  year={1991},
  volume={228},
  pages={372-380}
}
Three open reading frames (ORFs) in the actII region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2), which are involved in the export of the antibiotic are carried on two divergent transcripts. A monocistronic transcript carries actII-ORF1, encoding a putative repressor protein, and a bicistronic transcript codes for actII-ORF2 and -ORF3, whose products have been postulated to form an antibiotic export complex. The actll-ORF1 and actll-ORF2/3 transcripts each… CONTINUE READING

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