Transcriptional noise and the fidelity of initiation by RNA polymerase II

@article{Struhl2007TranscriptionalNA,
  title={Transcriptional noise and the fidelity of initiation by RNA polymerase II},
  author={Kevin Struhl},
  journal={Nature Structural \&Molecular Biology},
  year={2007},
  volume={14},
  pages={103-105}
}
  • K. Struhl
  • Published 1 February 2007
  • Biology, Medicine
  • Nature Structural &Molecular Biology
Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo. I suggest that 90% of Pol II initiation events in yeast represent transcriptional noise, and that the specificity of initiation is comparable to that of DNA-binding proteins and other biological processes. This emphasizes the need to develop criteria that distinguish transcriptional noise from transcription with a biological function. 
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TLDR
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