Transcriptional networks in developing and mature B cells

  title={Transcriptional networks in developing and mature B cells},
  author={Patrick D. Matthias and Antonius G. Rolink},
  journal={Nature Reviews Immunology},
The development of B cells from haematopoietic stem cells proceeds along a highly ordered, yet flexible, pathway. At multiple steps along this pathway, cells are instructed by transcription factors on how to further differentiate, and several check-points have been identified. These check-points are initial commitment to lymphocytic progenitors, specification of pre-B cells, entry to the peripheral B-cell pool, maturation of B cells and differentiation into plasma cells. At each of these… CONTINUE READING

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