Transcriptional network dynamics in macrophage activation.

  title={Transcriptional network dynamics in macrophage activation.},
  author={Roland Nilsson and Vladimir B. Bajic and Harukazu Suzuki and Diego di Bernardo and Johan Bj{\"o}rkegren and Shintaro Katayama and James F. Reid and Matthew J Sweet and Manuela Gariboldi and Piero Carninci and Yoshihide Hayashizaki and David A. Hume and Jesper Tegn{\'e}r and Timothy Ravasi},
  volume={88 2},
Transcriptional regulatory networks govern cell differentiation and the cellular response to external stimuli. However, mammalian model systems have not yet been accessible for network analysis. Here, we present a genome-wide network analysis of the transcriptional regulation underlying the mouse macrophage response to bacterial lipopolysaccharide (LPS). Key to uncovering the network structure is our combination of time-series cap analysis of gene expression with in silico prediction of… CONTINUE READING


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