Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse.

@article{Hu2011TranscriptionalMH,
  title={Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse.},
  author={Yi Hu and Vanita Chopra and Raman Chopra and Joseph J Locascio and Zhixiang Liao and Hongliu Ding and Bin Zheng and Wayne R. Matson and Robert Ferrante and H. Diana Rosas and Steven M. Hersch and Clemens R Scherzer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 41},
  pages={17141-6}
}
Huntington disease (HD) is a progressive neurodegenerative disease that affects 30,000 individuals in North America. Treatments that slow its relentless course are not yet available, and biomarkers that can reliably measure disease activity and therapeutic response are urgently needed to facilitate their development. Here, we interrogated 119 human blood samples for transcripts associated with HD. We found that the dynamic regulator of chromatin plasticity H2A histone family, member Y (H2AFY… CONTINUE READING
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