Transcriptional mechanisms of chondrocyte differentiation.

  title={Transcriptional mechanisms of chondrocyte differentiation.},
  author={Benoit de Crombrugghe and Veronique Lefebvre and Richard R. Behringer and Weimin Bi and Shunichi Murakami and Wei Huang},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  volume={19 5},
With the goal of identifying master transcription factors that control the genetic program of differentiation of mesenchymal cells into chondrocytes, we first delineated a 48-bp chondrocyte-specific enhancer element in the gene for proalpha1(II) collagen (Col2a1), an early and abundant marker of chondrocytes. Our experiments have demonstrated that the HMG-box-containing transcription factor, Sox9 which binds and activates this enhancer element, is required for chondrocyte differentiation and… CONTINUE READING


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