Transcriptional mechanisms of acute lung injury.

  title={Transcriptional mechanisms of acute lung injury.},
  author={Jie Fan and Richard D Ye and Asrar B. Malik},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={281 5},
Acute lung injury occurs as a result of a cascade of cellular events initiated by either infectious or noninfectious inflammatory stimuli. An elevated level of proinflammatory mediators combined with a decreased expression of anti-inflammatory molecules is a critical component of lung inflammation. Expression of proinflammatory genes is regulated by transcriptional mechanisms. Nuclear factor-kappa B (NF-kappa B) is one critical transcription factor required for maximal expression of many… CONTINUE READING
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