Transcriptional interferences at the Hoxa4/Hoxa5 locus: importance of correct Hoxa5 expression for the proper specification of the axial skeleton.

@article{Aubin1998TranscriptionalIA,
  title={Transcriptional interferences at the Hoxa4/Hoxa5 locus: importance of correct Hoxa5 expression for the proper specification of the axial skeleton.},
  author={Jos{\'e}e Aubin and Margot Lemieux and Maxime Tremblay and Richard R. Behringer and Lucie Jeannotte},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={1998},
  volume={212 1},
  pages={141-56}
}
We have previously described a Hoxa5 mutant mouse line in which specification of axial identity is perturbed and viability is markedly reduced. In the present study, we assay the Hoxa5 mutation in different genetic backgrounds and carry out a complete analysis of skeletal transformations. Although Hoxa5 is expressed over a large domain during embryogenesis, homeotic transformations of the axial skeleton are confined between cervical vertebra C3 and thoracic vertebra T2, which corresponds to the… CONTINUE READING
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