Transcriptional interference between glucocorticoid receptor and estradiol receptor mediates the inhibitory effect of cortisol on fish vitellogenesis.

@article{Lethimonier2000TranscriptionalIB,
  title={Transcriptional interference between glucocorticoid receptor and estradiol receptor mediates the inhibitory effect of cortisol on fish vitellogenesis.},
  author={Christ{\`e}le Lethimonier and Gilles Flouriot and Yves Valotaire and Olivier Kah and Bernadette Ducouret},
  journal={Biology of reproduction},
  year={2000},
  volume={62 6},
  pages={1763-71}
}
In oviparous species, the synthesis of vitellogenin (Vg) takes place in the liver according to a strictly estrogen-dependent mechanism that first involves an up-regulation of the estrogen receptor (ER) by its own ligand. However, reports from the literature indicate that in trout stress or cortisol may cause a reduction of cytosolic E2-binding sites in the liver and a decrease in plasma Vg levels. To investigate the mechanisms underlying these effects, in vivo and in vitro experiments were… CONTINUE READING

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