Transcriptional induction of two genes in human cells by beta interferon.

  title={Transcriptional induction of two genes in human cells by beta interferon.},
  author={Andrew C Larner and Gerald J Jonak and Yuan Shan Cheng and Bruce Korant and Ellie Knight and J. E. Darnell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={81 21},
The binding of interferons to distinct cell surface receptors leads to the induction of synthesis of several unique polypeptides and their corresponding mRNAs (1-6). We have isolated two cDNAs that are complementary to nuclear RNA whose synthesis is induced from undetectable levels to maximal rates of transcription within 30-60 min after the addition of beta interferon to human fibroblasts or to HeLa cells. These results prove that a single polypeptide can, by binding to a specific plasma… CONTINUE READING