Transcriptional induction of endothelial nitric oxide synthase type III by lysophosphatidylcholine.

  title={Transcriptional induction of endothelial nitric oxide synthase type III by lysophosphatidylcholine.},
  author={Arthur Zembowicz and Jie Tang and Kenneth K. Wu},
  journal={The Journal of biological chemistry},
  volume={270 28},
Endothelial synthesis of NO is catalyzed by constitutive NO synthase type III (NOS-III). NOS-III has been thought to be regulated mainly at the level of enzyme activity by intracellular calcium. We report that in human umbilical vein endothelial cells lysophosphatidylcholine (lyso-PC), a component of atherogenic lipoproteins and atherosclerotic lesions, increases NOS-III mRNA and protein levels. This leads to the augmentation of NOS-III activity and the enhancement of antiplatelet properties of… CONTINUE READING

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