Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta.

  title={Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta.},
  author={Naro Ohashi and Tatsuo Yamamoto and Chiharu Uchida and Akashi Togawa and Hirotaka Fukasawa and Yoshihide Fujigaki and Sayuri Suzuki and Kyoko Kitagawa and Takayuki Hattori and Toshiaki Oda and Hidetoshi Hayashi and Akira Hishida and Masatoshi Kitagawa},
  journal={FEBS letters},
  volume={579 12},
Smad ubiquitination regulatory factor 2 (Smurf2), a ubiquitin ligase for Smads, plays critical roles in the regulation of transforming growth factor-beta (TGF-beta)-Smad signaling via ubiquitin-dependent degradation of Smad2 and Smad7. We found that TGF-beta stimulates Smurf2 expression. TGF-beta activated the Smurf2 promoter in a TGF-beta responsive cell lines, whereas IL-1alpha, PDGF and epidermal growth factor did not. TGF-beta-mediated Smurf2 promoter activation was inhibited by Smad7 or an… CONTINUE READING


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