Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation.

  title={Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation.},
  author={Jie Jack Li and Myriam Gorospe and Dorothy Hutter and Janice Barnes and Stephen M. Keyse and Yingqiu Yvette Liu},
  journal={Molecular and cellular biology},
  volume={21 23},
Mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1) has been shown to play a critical role in mediating the feedback control of MAP kinase cascades in a variety of cellular processes, including proliferation and stress responsiveness. Although MKP-1 expression is induced by a broad array of extracellular stimuli, the mechanisms mediating its induction remain poorly understood. Here we show that MKP-1 mRNA was potently induced by arsenite and ultraviolet light and modestly increased by… CONTINUE READING


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