Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells.

@article{Wang2004TranscriptionalIO,
  title={Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells.},
  author={Li Hua O. Wang and Xiao Yi Yang and Xiaohu Zhang and Jiaqiang Huang and Jian Hou and Jie Li and Hong Xiong and Kelly Mihalic and Heming Zhu and Weihua Xiao and William L. Farrar},
  journal={Immunity},
  year={2004},
  volume={20 2},
  pages={205-18}
}
Multiple myeloma (MM) remains largely incurable despite conventional and high-dose therapies. Therefore, novel biologically based treatment approaches are urgently required. Here we demonstrate that expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in MM cells and its agonists 15-d-PGJ2 and troglitazone completely abolished IL-6… CONTINUE READING