Transcriptional functions of a new mammalian TATA-binding protein-related factor.

  title={Transcriptional functions of a new mammalian TATA-binding protein-related factor.},
  author={Edio Maldonado},
  journal={The Journal of biological chemistry},
  volume={274 19},
A mammalian protein highly homologous to TATA-binding protein (TBP) has been identified and cloned. The recombinant mammalian TBP-related factor binds to the TATA box of the Ad-MLP and forms stable complexes with TFIIB on the promoter DNA. The mammalian TBP-related factor is able to substitute for TBP in supporting transcription by RNA polymerase II in an in vitro reconstituted system. 

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