Transcriptional establishment of cell-type identity: dynamics and causal mechanisms of T-cell lineage commitment.

@article{Rothenberg2013TranscriptionalEO,
  title={Transcriptional establishment of cell-type identity: dynamics and causal mechanisms of T-cell lineage commitment.},
  author={Ellen V Rothenberg and Ameya Champhekar and Sagar S. Damle and Marissa Morales Del Real and Hao Yuan Kueh and Long Li and Mary Yui},
  journal={Cold Spring Harbor symposia on quantitative biology},
  year={2013},
  volume={78},
  pages={31-41}
}
Precursor cell entry into the T-cell developmental pathway can be divided into two phases by the closure of T-lineage commitment. As cells decide against the last alternative options to the T-cell fate, they turn on the transcription factor Bcl11b and silence expression of a group of multipotent progenitor regulatory factors that include hematopoietic transcription factor PU.1. Functional perturbation tests show that Bcl11b is needed for commitment while PU.1 actively participates in keeping… CONTINUE READING
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