Transcriptional enhancers: functional insights and role in human disease.

Abstract

In recent years, studies of cis-regulatory mechanisms have evolved from a predominant focus on promoter regions to the realization that spatial and temporal gene regulation is frequently driven by long-range enhancer clusters that operate within chromosomal compartments. This increased understanding of genome function, together with the emergence of… (More)
DOI: 10.1016/j.gde.2015.08.009

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