Transcriptional elongation requires DNA break-induced signalling

@article{Bunch2015TranscriptionalER,
  title={Transcriptional elongation requires DNA break-induced signalling},
  author={Heeyoun Bunch and Brian P. Lawney and Yu-Fen Lin and A. Asaithamby and A. Murshid and Yaoyu E. Wang and Benjamin P C Chen and S. Calderwood},
  journal={Nature Communications},
  year={2015},
  volume={6}
}
We have previously shown that RNA polymerase II (Pol II) pause release and transcriptional elongation involve phosphorylation of the factor TRIM28 by the DNA damage response (DDR) kinases ATM and DNA-PK. Here we report a significant role for DNA breaks and DDR signalling in the mechanisms of transcriptional elongation in stimulus-inducible genes in humans. Our data show the enrichment of TRIM28 and γH2AX on serum-induced genes and the important function of DNA-PK for Pol II pause release and… Expand
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