Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Δ Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51

@article{Senoo2001TranscriptionalDO,
  title={Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Δ Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51},
  author={Makoto Senoo and Izumi Tsuchiya and Yoshihito Matsumura and Toshio Mori and Yuki Saito and H. Ogata H. Kato and Takashi Okamoto and Sonoko Habu},
  journal={British Journal of Cancer},
  year={2001},
  volume={84},
  pages={1235 - 1241}
}
We have recently identified a second p53 -related p73L gene, also referred to as p63/p51/p40/KET gene, which encodes the 2 major isoforms p73L and p51 resulting from different exon usage at their amino terminal regions. Although p73L and p51 are suspected to play oncogenic and tumour suppressive roles in mammalian cells, respectively, no evidence of linkage between the expression of these isoforms and human cancers has been reported so far. In this study, we first investigated the expression… CONTINUE READING

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