Transcriptional dysregulation during myeloid transformation in AML

  title={Transcriptional dysregulation during myeloid transformation in AML},
  author={Thomas Pabst and Beatrice U. Mueller},
The current paradigm on leukemogenesis indicates that leukemias are propagated by leukemic stem cells. The genomic events and pathways involved in the transformation of hematopoietic precursors into leukemic stem cells are increasingly understood. This concept is based on genomic mutations or functional dysregulation of transcription factors in malignant cells of patients with acute myeloid leukemia (AML). Loss of the CCAAT/enhancer binding protein-α (CEBPA) function in myeloid cells in vitro… CONTINUE READING
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