Transcriptional downregulation of DC-SIGN in human herpesvirus 6-infected dendritic cells.

  title={Transcriptional downregulation of DC-SIGN in human herpesvirus 6-infected dendritic cells.},
  author={Hironari Niiya and Taichi Azuma and Lei Jin and Naoyuki Uchida and Atsushi Inoue and Hitoshi Hasegawa and Shigeru Fujita and Mikiko Tohyama and Koji Hashimoto and Masaki Yasukawa},
  journal={The Journal of general virology},
  volume={85 Pt 9},
DC-SIGN expressed on dendritic cells (DCs) efficiently binds and transmits various pathogens, including human immunodeficiency virus, to lymphoid tissues and permissive cells. Consequently, alteration of DC-SIGN expression may affect susceptibility and resistance to pathogens. The present study shows that infection with human herpesvirus 6 (HHV-6) induces downregulation of DC-SIGN expression on immature DCs. Expression levels of DC-SIGN mRNA and intracellular protein appeared to decrease… CONTINUE READING
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