Transcriptional deregulation of homeobox gene ZHX2 in Hodgkin lymphoma.

Abstract

Recently, we identified a novel chromosomal rearrangement in Hodgkin lymphoma (HL), t(4;8)(q27;q24), which targets homeobox gene ZHX2 at the recurrent breakpoint 8q24. This aberration deletes the far upstream region of ZHX2 and results in silenced transcription pinpointing loss of activatory elements. Here, we have looked for potential binding sites within… (More)
DOI: 10.1016/j.leukres.2011.10.019

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