Transcriptional defects underlie loss of E-cadherin expression in breast cancer.

  title={Transcriptional defects underlie loss of E-cadherin expression in breast cancer.},
  author={Xuhuai Ji and Amy S. Woodard and David L. Rimm and Eric R. Fearon},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  volume={8 7},
Decreased expression of E-cadherin (E-cad), a calcium-dependent cell adhesion molecule, has been seen in many different epithelial cancers. Although somatic mutations in the E-cad gene have been identified in a small subset of tumors, in the majority of cancers, the mechanisms underlying loss of E-cad expression are poorly understood. We have cloned the human E-cad promoter and defined its critical components in functional assays. In eight human breast cancer cell lines, there was a striking… CONTINUE READING
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