Transcriptional control of the pref-1 gene in 3T3-L1 adipocyte differentiation. Sequence requirement for differentiation-dependent suppression.

@article{Smas1998TranscriptionalCO,
  title={Transcriptional control of the pref-1 gene in 3T3-L1 adipocyte differentiation. Sequence requirement for differentiation-dependent suppression.},
  author={Cynthia M. Smas and D J Kachinskas and C M Liu and Xun Xie and Lori Dircks and Hei Sook Sul},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 48},
  pages={31751-8}
}
Preadipocyte factor-1 (Pref-1) is a transmembrane epidermal growth factor-like domain-containing protein highly expressed in 3T3-L1 preadipocytes, but is undetectable in mature fat cells; this down-regulation is required for adipocyte differentiation. We show here that pref-1 transcription is markedly suppressed during adipose conversion and results in decreased Pref-1 RNA levels. Using 3T3-L1 cells stably transfected with Pref-1 5'-deletion constructs truncated at -6000, -2100, -1300, -692… CONTINUE READING
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