Transcriptional control of the development and function of Vα14i NKT cells.

  title={Transcriptional control of the development and function of Vα14i NKT cells.},
  author={Isaac Engel and Mitchell Kronenberg},
  journal={Current topics in microbiology and immunology},
The majority of T lymphocytes, sometimes referred to as as mainstream or conventional T cells, are characterized by a diverse T cell antigen receptor (TCR) repertoire. They require antigen priming in order to become memory cells capable of mounting a rapid effector response. It has become established, however, that there are several distinct T cell lineages that exhibit a memory phenotype in the absence of antigen priming, even as they differentiate in the thymus. These lymphocytes typically… CONTINUE READING
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