Transcriptional control of the Saccharomyces cerevisiae PGK gene by RAP1.

@article{Chambers1989TranscriptionalCO,
  title={Transcriptional control of the Saccharomyces cerevisiae PGK gene by RAP1.},
  author={A. V. Chambers and Jimmy S. H. Tsang and Clive A. Stanway and Alan J. Kingsman and Susan M. Kingsman},
  journal={Molecular and cellular biology},
  year={1989},
  volume={9 12},
  pages={5516-24}
}
The promoter of the yeast glycolytic gene encoding phosphoglycerate kinase (PGK) contains an upstream activation sequence between bases -538 and -402 upstream of the initiating ATG. The upstream activation sequence contains multiple functional elements, including an essential region called the activator core (AC) sequence and three copies of the pentamer 5'-CTTCC-3'. The AC sequence shows strong homology to the consensus binding sites for the yeast proteins RAP1 (GRF1) and TUF. We have… CONTINUE READING