Transcriptional control of osteoblast growth and differentiation.

  title={Transcriptional control of osteoblast growth and differentiation.},
  author={Gary S Stein and Jane B Lian and Janet L Stein and Andre J van Wijnen and Mart{\'i}n A. Montecino},
  journal={Physiological reviews},
  volume={76 2},
Osteoblast differentiation is a multistep series of events modulated by an integrated cascade of gene expression that initially supports proliferation and the sequential expression of genes associated with the biosynthesis, organization, and mineralization of the bone extracellular matrix. Transcriptional control defines regulatory events operative both developmentally and for support of bone tissue-specific properties. This review focuses on components of transcriptional regulation that… CONTINUE READING

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