Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes.

@article{Piantadosi2012TranscriptionalCO,
  title={Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes.},
  author={Claude A. Piantadosi and Hagir B. Suliman},
  journal={Biochimica et biophysica acta},
  year={2012},
  volume={1820 4},
  pages={532-41}
}
BACKGROUND Cells avoid major mitochondrial damage and energy failure during systemic inflammatory states, such as severe acute infections, by specific targeting of the inflammatory response and by inducing anti-inflammatory and anti-oxidant defenses. Recent evidence indicates that these cell defenses also include mitochondrial biogenesis and the clearance of damaged mitochondria through autophagy. SCOPE OF REVIEW This review addresses a group of transcriptional signaling mechanisms that… CONTINUE READING

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