Transcriptional control of melanoma metastasis: the importance of the tumor microenvironment.

@article{Braeuer2011TranscriptionalCO,
  title={Transcriptional control of melanoma metastasis: the importance of the tumor microenvironment.},
  author={Russell R. Braeuer and Maya Zigler and Gabriel J. Villares and Andrey S Dobroff and Menashe M Bar-Eli},
  journal={Seminars in cancer biology},
  year={2011},
  volume={21 2},
  pages={83-8}
}
The molecular changes associated with the transition of melanoma cells from radial growth phase (RGP) to vertical growth phase (VGP) and the metastatic phenotype are not very well defined. However, some of the genes involved in this process and their transcriptional regulation are beginning to be elucidated. For example, the switch from RGP to VGP and the metastatic phenotype is associated with loss of the AP-2α transcription factor. AP-2α regulates the expression of c-KIT, MMP-2, VEGF, and the… CONTINUE READING

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