Transcriptional control of maladaptive and protective responses in alcoholics: A role of the NF-κB system

@article{Yakovleva2011TranscriptionalCO,
  title={Transcriptional control of maladaptive and protective responses in alcoholics: A role of the NF-κB system},
  author={Tatjana Yakovleva and Igor Bazov and Hiroyuki Watanabe and Kurt F Hauser and Georgy Bakalkin},
  journal={Brain, Behavior, and Immunity},
  year={2011},
  volume={25},
  pages={s29-s38}
}
Alcohol dependence and associated cognitive impairment appear to result from maladaptive neuroplasticity in response to chronic alcohol consumption, neuroinflammation and neurodegeneration. The inherent stability of behavioral alterations associated with the addicted state suggests that transcriptional and epigenetic mechanisms are operative. NF-κB transcription factors are regulators of synaptic plasticity and inflammation, and responsive to a variety of stimuli including alcohol. These… CONTINUE READING

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