Transcriptional control of cardiac allograft vasculopathy by early growth response gene-1 (Egr-1).

@article{Okada2002TranscriptionalCO,
  title={Transcriptional control of cardiac allograft vasculopathy by early growth response gene-1 (Egr-1).},
  author={Morihito Okada and Catherine Y. Wang and Daniel W Hwang and Taichi Sakaguchi and Kim E. Olson and Yasushi Yoshikawa and Kanji Minamoto and Sean P. Mazer and S G Yan and David J. Pinsky},
  journal={Circulation research},
  year={2002},
  volume={91 2},
  pages={135-42}
}
Expression of the zinc finger transcription factor early growth response gene-1 (Egr-1) is triggered rapidly after mechanical vascular injury or after a precipitous drop in ambient oxygen, whereupon it induces the expression of diverse gene families to elicit a pathological response. Initially characterized as an early response transcriptional activator, the role of Egr-1 in more chronic forms of vascular injury remains to be defined. Studies were designed to examine whether Egr-1 induction may… CONTINUE READING