Transcriptional control of apolipoprotein A-I gene expression in diabetes.

@article{Mooradian2004TranscriptionalCO,
  title={Transcriptional control of apolipoprotein A-I gene expression in diabetes.},
  author={Arshag D Mooradian and Michael J. Haas and Norman C. W. Wong},
  journal={Diabetes},
  year={2004},
  volume={53 3},
  pages={513-20}
}
Cardiovascular disease continues to be the leading cause of mortality in diabetes. One of the factors contributing to the increased risk is the high prevalence rate of low plasma concentrations of HDL cholesterol. Multiple potential mechanisms account for the cardioprotective effects of HDL and its main protein apolipoprotein (apo) A-I. The reduced plasma concentrations of HDL could be the result of increased fractional clearance of HDL and reduced expression of apo A-I. In animal models of… CONTINUE READING
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