Transcriptional control mechanism of fibrinogen gene expression.

@article{Fuller2001TranscriptionalCM,
  title={Transcriptional control mechanism of fibrinogen gene expression.},
  author={Gerald M. Fuller and Zhuo Zhang},
  journal={Annals of the New York Academy of Sciences},
  year={2001},
  volume={936},
  pages={
          469-79
        }
}
Although fibrinogen genes are expressed constitutively in hepatocytes, their transcription can be greatly increased during inflammatory stress. Extensive studies have focused on the cytokine mediated transcriptional regulation of fibrinogen genes. It is clear that interleukin-6 (IL-6) and its family of cytokines are the major inducers of fibrinogen gene expression. Functional analyses of all three fibrinogen promoters for human and rat all demonstrate that the conserved CTGGGAA motifs within… CONTINUE READING
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